Director, Safety Risk Lead (MD) – Pfizer | United States (Hybrid)
Locations: Groton, Connecticut | Collegeville, Pennsylvania | New York City, New York
Job Type: Full-Time
Job ID: 4944903
Posted: 15 Days Ago
About the Role
Pfizer is seeking a highly experienced Director, Safety Risk Lead (MD) to provide strategic medical safety leadership across its global portfolio. This position plays a critical role in shaping safety surveillance, benefit–risk evaluation and regulatory interactions throughout the full lifecycle of Pfizer products—from early clinical development through post-market stages.
This role requires an expert medical safety professional capable of exercising sound clinical judgment, driving cross-functional safety initiatives, and advocating for patient safety while supporting global regulatory expectations.
This is a hybrid role, requiring on-site presence an average of 2.5 days per week.
Key Responsibilities
Safety Leadership & Governance
Serve as the primary safety contact for assigned Asset Teams.
Chair Risk Management Committees (RMCs) and Core Working Groups with minimal oversight.
Represent Worldwide Safety (WWS) in internal governance forums and external engagements with regulatory authorities and business partners.
Safety Surveillance & Risk Management
Conduct comprehensive safety data evaluation from all sources.
Identify and assess safety signals, presenting medical evaluations and benefit–risk assessments to cross-functional teams.
Develop independent action plans addressing safety and risk-minimization issues.
Ensure alignment of safety messaging across multiple indications and business units.
Strategic & Operational Excellence
Lead and enhance safety surveillance methodologies, standards, and processes.
Contribute to continuous improvement, innovation initiatives, and Safety Sciences Research activities.
Support inspection readiness and maintain high-quality safety documentation.
Cross-functional Collaboration & Mentorship
Partner with Regulatory, Clinical, Quality, Medical, and Corporate Audit teams.
Provide medical expertise on pharmacovigilance and therapeutic areas.
Mentor and coach colleagues, fostering a culture of excellence and accountability.
Required Qualifications & Experience
MD degree with minimum 4+ years of relevant experience in:
Clinical practice, clinical trials, academic medicine, or specialty training
Pharmacovigilance, medical safety, or drug development
Strong background in endocrinology, obesity, and metabolism (mandatory).
Deep understanding of safety risk management, global regulatory guidelines, and drug-development processes.
Proven experience in benefit–risk assessment, signal detection, and safety data evaluation.
Ability to lead matrixed teams and influence diverse internal and external stakeholders.
Strong medical and scientific literature fluency; understanding of statistics and analytical tools.
Demonstrated leadership, communication, and decision-making skills.
Technical Skills
Expertise in aggregate safety data review, clinical safety signal identification, and risk-minimization planning.
Understanding of therapeutic mechanisms, drug-induced diseases, and disease-area specific pharmacology.
Knowledge of global pharmacovigilance regulations and inspection expectations.
Ability to integrate complex data to support clinical and regulatory benefit–risk decisions.
Compensation & Benefits
Annual Base Salary: USD 219,800 – 366,400
Eligible for Pfizer Global Performance Bonus (25% target)
Eligibility for Long-Term Share-Based Incentive Program
Comprehensive benefits package, including:
401(k) with matching
Retirement Savings Contribution
Medical, dental, vision coverage
Paid vacation, holidays, caregiver/parental leave
Additional health and wellness benefits
Compensation varies by location. Tampa, FL and regions outside the U.S. are excluded from this range.
Additional Information
Relocation support may be available based on eligibility.
Permanent U.S. work authorization required.
Pfizer complies fully with equal employment opportunity laws and employment eligibility verification.
Pfizer participates in E-Verify.
Licensed physicians may be subject to federal reporting under the Sunshine Act for reimbursed recruiting or interview expenses.
How to Apply
Interested candidates can submit their application through Pfizer’s official career portal.
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