Principal Scientist, Computational Biotherapeutics Engineering

Pfizer

2+ years

$99,900 to $166,500

La Jolla

10 Dec. 26, 2024

Job Description

Job Type: Full Time Education: PhD Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

The Protein Structure Modeling Expert position at Pfizer is designed for a specialist with a strong background in protein design, computational analysis, and AI/ML-based property prediction. This role focuses on optimizing protein-based therapeutic leads (such as antibodies, multi-specifics, and fusion proteins) and involves close collaboration with project teams to drive innovation in the design of biotherapeutics.

Role Responsibilities:

Protein Design and Computational Analysis:
- Provide expertise in structure and AI-based computational analysis of protein therapeutics.
- Work with project teams to optimize protein biotherapeutic leads, using computational models to design improved candidates.
- Communicate findings and recommendations clearly to colleagues from diverse scientific backgrounds.
Development of Computational Workflows:
- Implement and evaluate new methods to enhance the throughput and accuracy of molecular modeling workflows.
- Analyze data sets to uncover relationships between protein structure and key pharmaceutical properties.
- Engineer improved platforms for protein therapeutics and RNA vaccines.
AI and Machine Learning Integration:
- Utilize AI tools for protein design and property prediction, probing their limits to improve therapeutic outcomes.
- Develop and refine AI/ML models to optimize biotherapeutic properties.
Cross-Department Collaboration:
- Work with colleagues from various departments to integrate new methods and improve the design process.
- Contribute to the development of analysis workflows usable by other teams.

Basic Qualifications:

Education: PhD in biochemistry, chemistry, or a related field with experience in the biopharmaceutical industry.
Experience:
- Strong track record in protein design or property optimization using computational methods (structure-based and AI/ML-based).
- Publication history in protein design or related areas.
- Experience with AI tools for protein design and/or property prediction.
- Expertise in one or more protein structure modeling software packages.
- Experience with programming in Linux environments (using Perl, Python, Matlab, Jupyter Notebook, etc.).
Technical Skills:
- Working knowledge of bioinformatics tools and databases.
- Ability to conduct research projects and present results to scientists with experimental backgrounds.

Preferred Qualifications:

Knowledge of antibody structure and function.
Experience with RNA structure prediction and optimization.
Familiarity with Linux systems administration and HPC environments.
Experience with software suites such as Schrodinger, Rosetta, Discovery Studio, FoldX, MOE.
Ability to integrate multiple scientific software toolkits to create new analysis workflows.

Physical/Mental Requirements:

Ability to perform complex data analysis effectively.

Work Schedule and Travel Requirements:

May involve occasional early morning meetings with colleagues in Dublin or the US eastern time zone.
Work Location: Hybrid (partially remote, partially in-office).

Salary & Benefits:

Salary Range: $99,900 to $166,500 annually, with a bonus target of 15% of base salary.
Benefits: Includes 401(k) plan with Pfizer matching, retirement savings contributions, paid leave, health coverage (medical, dental, vision), and more.

Sunshine Act Compliance:

Pfizer reports payments and transfers of value to healthcare providers in compliance with federal and state laws. This may include recruiting expenses for licensed physicians.

EEO & Employment Eligibility:

Pfizer is an equal opportunity employer and complies with all applicable laws regarding non-discrimination and work authorization.

This role offers the opportunity to work on cutting-edge biotherapeutics, utilizing advanced computational tools and AI/ML models, and collaborating with a diverse team of scientists to drive innovations in protein design and therapeutic optimization.

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Principal Scientist, Computational Biotherapeutics Engineering

Job Description

Role Responsibilities:

Basic Qualifications:

Preferred Qualifications:

Physical/Mental Requirements:

Work Schedule and Travel Requirements:

Salary & Benefits:

Sunshine Act Compliance:

EEO & Employment Eligibility:

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