Principal Site Grant Manager | Clinical Trials | US – Hybrid (Morrisville, NC)
Location: USA – NC, Morrisville (Hybrid)
Job Type: Full-Time
Job ID: 25104681
About Syneos Health
Syneos Health® is a leading global biopharmaceutical solutions organization that accelerates clinical development, medical affairs, and commercial strategies. Our model places the patient and customer at the center, ensuring efficient clinical operations, high-quality outcomes, and continuous innovation.
With 29,000 employees across 110 countries, Syneos Health fosters a culture of career growth, inclusion, and collaboration, supporting employees to excel in a competitive and dynamic industry.
Role Overview
The Principal Site Grant Manager plays a strategic and leadership role in investigator budget management and site contracting. This position is a subject matter expert in site grant development, fair market value assessment, and budget negotiation for clinical trials.
This role involves high-level collaboration with sponsors, internal stakeholders, and project teams, ensuring investigator budgets and grant templates are accurate, compliant, and aligned with global operational strategies.
The Principal Site Grant Manager also coaches, trains, and mentors junior team members, and drives process improvements and best practices across the organization.
Key Responsibilities
Strategic Budget & Grant Management
Serve as subject matter expert for global site budgeting and grant processes, providing guidance and solutions to complex issues.
Develop, update, and validate investigator grant budgets and country templates based on protocol specifications and sponsor requirements.
Ensure budgets reflect fair market value, operational feasibility, and sponsor agreements.
Collaborate with internal stakeholders and sponsors to harmonize budgets, negotiate payment terms, and resolve escalations.
Identify potential operational or financial risks and implement solutions proactively.
Leadership & Process Improvement
Establish and maintain training materials for budget and site contract teams.
Coach, mentor, and guide junior staff on SOPs, tools, and processes.
Lead internal initiatives to standardize budgeting practices and implement continuous process improvements.
Participate in business development discussions as a subject matter expert in investigator budgets and fair market value.
Documentation & Compliance
Maintain accurate records, reports, and documentation for budgets, grants, and related processes.
Ensure compliance with company policies, SOPs, and regulatory requirements.
Collaborate with legal, finance, and clinical operations teams on complex budgeting and contracting issues.
Required Qualifications
Education & Experience
BS degree in life sciences, healthcare, or related field, or equivalent experience.
Extensive experience in CRO/pharmaceutical industry, clinical trials, site start-up, or related functional areas.
Strong understanding of clinical project management, regulations, and drug development processes.
Skills & Competencies
Exceptional leadership, mentoring, and team management skills.
Excellent communication, presentation, and interpersonal abilities.
Proficiency in MS Office (Word, Excel, PowerPoint), MS Project, Outlook, and web-based tools.
Ability to manage multiple tasks, deadlines, and complex projects in a dynamic environment.
Strong analytical skills with an attention to detail and independent decision-making capabilities.
Travel: Minimal, up to 25%
Why Join Syneos Health
Lead investigator budget strategy and site grant processes at a global level.
Collaborate with cross-functional teams and sponsors to drive project success.
Influence operational excellence and best practices across the organization.
Access career development opportunities, training programs, and professional growth.
Enjoy comprehensive benefits including health coverage, 401k matching, stock purchase plan, flexible PTO, and performance-based incentives.
Apply Now
Advance your career as a Principal Site Grant Manager, taking a strategic leadership role in site grant management, investigator budget development, and clinical trial operations with a global leader in biopharmaceutical solutions.
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