Scientist – Upstream Process Development (Mammalian) | Biosimilars
Location: Pune, Maharashtra, India
Employment Type: Permanent
Department: Upstream Process Development (UPD)
Experience Required: 8–11 Years
Job Posted On: January 09, 2026
Job Overview
We are seeking an experienced Scientist – Upstream Process Development (Mammalian) to support biosimilar development programs. The role focuses on mammalian cell culture process development, optimization, and scale-up using advanced bioreactor systems. The ideal candidate will bring strong technical expertise in fed-batch and perfusion processes, hands-on bioreactor experience, and the ability to collaborate across cross-functional teams in a fast-paced R&D environment.
This position is based in Pune, India, and offers an opportunity to contribute to high-impact biosimilar development projects within a permanent role.
Key Responsibilities – Upstream Process Development (Mammalian)
Design, plan, and execute media and feed screening studies using ambr250 systems and laboratory-scale bioreactors.
Develop and optimize mammalian cell culture processes, including fed-batch and perfusion strategies.
Perform bioreactor culture development at laboratory and pilot scales (2L to 50L) using glass and single-use technologies.
Operate and manage bench-top bioreactors, single-use systems, and high-throughput platforms such as ambr250, WAVE bioreactors, and ATF systems.
Apply strong aseptic techniques for mammalian cell culture across various lab-scale formats.
Conduct cell growth and process monitoring using instruments such as Cedex, Vi-Cell, and Osmometer.
Plan, assign, and supervise daily experimental activities to ensure accurate and timely execution.
Perform daily review and analysis of experimental data, ensuring scientific rigor and documentation compliance.
Review and contribute to technical and functional documents such as Process Development Reports (PDR) and Technical Transfer Documents (TTD).
Collaborate with cross-functional teams including research, development, manufacturing, and quality functions.
Demonstrate effective problem-solving skills and contribute to continuous process improvement initiatives.
Act as a committed team player with strong interpersonal, written, and verbal communication skills.
Required Qualifications and Experience
Education: M.Tech or M.Sc. in Biotechnology, Biochemical Engineering, Biochemistry, Biology, or a related life sciences discipline.
Experience: Minimum 8 to 11 years of hands-on experience in mammalian upstream process development, preferably within biosimilars or biologics development.
Proven expertise in fed-batch and perfusion cell culture processes.
Strong working knowledge of single-use and stainless-steel bioreactor systems.
Experience working in a fast-paced, cross-functional pharmaceutical or biopharmaceutical R&D environment.
Excellent communication, presentation, and documentation skills.
Key Skills and Competencies
Mammalian Cell Culture
Upstream Process Development (UPD)
Biosimilars and Biologics
Fed-Batch and Perfusion Processes
ambr250, WAVE, ATF Systems
Bioreactor Scale-Up
Technical Documentation (PDR, TTD)
Cross-Functional Collaboration
Why Join Us?
Work on cutting-edge biosimilar development programs
Opportunity to lead and influence upstream process innovation
Collaborative and growth-oriented scientific environment
Permanent role with long-term career stability
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