Job Title
Chemist - Oligonucleotide Chemistry
Location
Indianapolis, Indiana, United States
Company
Eli Lilly and Company
Category
Research & Development
Job Type
Full Time | Regular
Job ID
R-85251
Position Summary
The Chemist - Oligonucleotide Chemistry will join the Lilly Genetic Medicines (LGM) team, focusing on the discovery, development, and scale-up of therapeutic oligonucleotides. This position involves working within a multidisciplinary team to synthesize and analyze oligonucleotides such as ASO and siRNA, troubleshoot synthesis challenges, and collaborate on the development of RNAi-based clinical candidates.
Key Responsibilities
Discovery and Scale-Up of Oligonucleotides:
Lead the oligosynthesis scale-up group and collaborate with discovery chemistry teams.
Synthesize therapeutic oligonucleotides (ASO, siRNA, etc.) using automated solid-phase synthesizers.
Collaborate with analytical teams to ensure proper characterization and analysis of processed molecules.
Technical Problem Solving:
Overcome synthetic challenges and improve existing workflows.
Support the implementation of new technologies and workflows.
Troubleshoot issues during oligonucleotide processing.
Laboratory and Team Collaboration:
Manage laboratory equipment, inventory, and consumables.
Prioritize contractor work to meet critical timelines.
Collaborate with CMC and development teams to drive innovation.
Operational Excellence:
Streamline operations to reduce waste and enhance efficiency.
Maintain strong laboratory and analytical instrumentation skills (e.g., AKTA, Agilent LC-MS, UPLC).
Education and Experience
Bachelor's and/or Master's in Chemistry or a related scientific field.
1+ years of experience with oligonucleotides.
Additional Skills/Preferences
Preferred experience in solid-phase oligonucleotide synthesis.
Strong experience with AKTA Oligosynt or Oligopilot 100.
Experience with analytical instrumentation like AKTA, Agilent LC-MS, UPLC, and Vanquish LTQ.
Ability to meet critical deadlines in a fast-paced environment.
Strong communication, organizational, and record-keeping skills.
Compensation
Anticipated Salary: $63,000 - $162,800 annually.
Eligible for company bonus program (based on company and individual performance).
Benefits
401(k) plan and pension
Vacation and paid time off
Medical, dental, vision, and prescription drug benefits
Flexible spending accounts (healthcare, dependent care)
Life insurance and death benefits
Wellness programs (EAP, fitness benefits, clubs, and activities)
Other leave of absence benefits
Travel
No travel specified.
Telecommuting
Telecommuting benefit available.
On-Site Position
Located at Indianapolis, IN.
Equal Opportunity Employer
Lilly is an equal opportunity employer dedicated to diversity and inclusion.
Employee Resource Groups (ERGs)
Includes groups such as Black Employees at Lilly, Organization of Latinx at Lilly (OLA), Lilly India Network, PRIDE (LGBTQ+ Allies), Women’s Initiative for Leading at Lilly (WILL), and others.
Accommodation
Applicants needing accommodations during the application process can request assistance via the Accommodation Request Form.
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