Senior Principal Scientist – Translational Medicine, Immunology
Location: South San Francisco, CA
Company: Merck & Co.
Job Type: Full-Time | Hybrid
Salary Range: $281,300 – $442,800 annually
Application Deadline: July 11, 2025
Job Summary
Merck & Co. is seeking an accomplished Senior Principal Scientist in Translational Medicine – Immunology to lead innovative early-stage clinical development and biomarker strategies. This leadership role is ideal for an experienced MD or MD/PhD with a strong background in immunology, especially in dermatology, rheumatology, or gastroenterology. Join Merck’s Translational Medicine team and help shape the future of immune-based therapies from discovery through Phase II clinical proof-of-concept.
Key Responsibilities
Lead early-stage clinical development and translational medicine strategy for immunology programs
Design and execute early clinical development plans, including biomarker strategy
Guide first-in-human, Phase 1a/b and pharmacology studies from preclinical to post-marketing phases
Contribute clinical expertise to target validation, including biomarker and imaging platform development
Oversee execution of Phase I trials in collaboration with cross-functional study teams
Provide expert input for regulatory submissions, marketing applications, and registration documents
Represent Translational Medicine in immunology-related business development assessments
Collaborate with global R&D teams across discovery, clinical, biomarker, and regulatory functions
Required Skills & Qualifications
MD or MD/PhD with 5+ years of pharma industry experience in clinical research
Proven expertise in immunology, preferably in dermatology, rheumatology, or gastroenterology
Track record of scientific achievement and scholarship
Experience in both patient care and clinical research
Strong leadership, communication, and cross-functional collaboration skills
Board Certification or Eligibility preferred
Preferred Skills
Hands-on experience with biomarker platforms, clinical imaging, or pharmacology tools
Familiarity with early clinical development strategy, IND submissions, and global regulatory expectations
Strong strategic thinking and innovative problem-solving in immunology drug development
Perks & Benefits
Competitive salary range: $281,300–$442,800
Annual bonus and long-term incentive eligibility
Full suite of benefits: medical, dental, vision, and 401(k)
Paid vacation, sick days, holidays, and wellness days
Hybrid work model – 3 days on-site per week
Relocation support and visa sponsorship available
Company Overview
Merck & Co. is a global leader in biopharmaceutical innovation, focused on advancing science for life. Our Translational Medicine team bridges discovery and clinical research to develop novel immunology-based therapies. With operations across major R&D hubs, Merck fosters a collaborative, diverse, and forward-thinking environment for scientific and clinical excellence.
Work Mode
Hybrid – Based in South San Francisco, CA, with flexibility to collaborate across other Merck R&D hubs
Call to Action
Ready to drive translational immunology research at the forefront of global pharma innovation?
Apply now and make an impact at Merck.
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