ob Title: Advisor – ADC Drug-Linker Synthetic Process Development
Location: Indianapolis, Indiana, United States
Category: Research & Development / Medicinal Chemistry / Biologics & ADCs
Job Type: Full-Time, Regular
Job ID: R-96226
Company Overview:
Lilly is a global healthcare leader headquartered in Indianapolis, Indiana, committed to improving patient outcomes worldwide. The Bioproduct Research and Development (BR&D) organization at Lilly focuses on developing and commercializing biologics, monoclonal antibodies, peptides, bioconjugates, cell and gene therapies, and other novel modalities. This multidisciplinary environment fosters collaboration across discovery, manufacturing, and quality teams.
Role Overview:
The Advisor – ADC Drug-Linker Synthetic Process Development will focus on the design, synthesis, and process development of small-molecule drug-linkers for Antibody-Drug Conjugates (ADCs). This role interfaces closely with biologics development, toxicology, and synthetic molecule design teams, supporting Lilly’s expanding pipeline of ADC therapeutics. The successful candidate will help grow chemistry infrastructure, advance highly-potent/cytotoxic drug-linker processes, and support internal and external manufacturing transfers.
Key Responsibilities:
1. Synthetic Process Development:
Design and develop robust synthetic processes for ADC drug-linkers and highly potent payloads.
Synthesize complex molecules for preclinical toxicology studies and early-phase development.
Collaborate across internal teams to implement and deliver materials and process data.
Apply unit operation design, process modeling, equipment selection, and scale-up strategies to support manufacturing.
2. Collaboration & Technical Leadership:
Partner with Discovery, Toxicology, and Bioconjugation teams to support new portfolio assets.
Provide leadership in scaling and demonstrating chemical processes in development-scale equipment.
Collaborate with external development and manufacturing organizations for process transfer and commercialization.
Support data generation for regulatory filings and address CMC-related questions for clinical studies.
3. Research & External Engagement:
Author technical reports and regulatory documents, including IND, IMPD, and BLA submissions.
Contribute to publications and presentations within the external chemistry community.
Assist in laboratory design and planning for highly-potent material handling.
Minimum Qualifications:
Ph.D. in synthetic organic chemistry or related discipline with 0–2 years of industry experience, OR
M.S. in chemistry with 5+ years of relevant industry experience in synthetic organic chemistry.
Preferred Skills & Attributes:
Experience handling high-potent or cytotoxic compounds.
Familiarity with Antibody-Drug Conjugates (ADCs).
Knowledge of preparative scale chromatographic purification of small molecules.
Strong scientific curiosity and interest in multidisciplinary pharmaceutical research.
Work Environment & Additional Information:
Potential exposure to chemicals, allergens, and loud noises.
Travel: 0–20%.
Full-time position based at Lilly Technology Center – North, Indianapolis, Indiana.
Compensation & Benefits:
Salary range: $126,000 – $204,600 (depending on experience and education).
Eligibility for company bonus based on individual and corporate performance.
Comprehensive benefits: 401(k), pension, medical, dental, vision, flexible spending accounts, life insurance, paid leave, wellness programs, and employee engagement activities.
Equal Opportunity & Inclusion:
Lilly is an EEO employer, providing equal opportunities regardless of age, race, color, religion, gender identity, sexual orientation, genetic information, disability, or other legally protected status.
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