Position Title:
Lead, Cancer Biology Research and Therapeutics, Disease Mechanism Research
Job ID: #25-POS00082887
Location:
South San Francisco, California, United States
About Astellas
Astellas Pharma Inc. is a global pharmaceutical company operating in more than 70 countries. We are dedicated to transforming innovative science into medical solutions that bring hope and value to patients and their families. Our commitment to addressing unmet medical needs, combined with strong ethics and integrity, drives us to improve health outcomes worldwide.
🔗 Learn more: www.astellas.com
Position Purpose & Scope
The Disease Mechanism Research (DMR) team seeks a scientific leader with deep expertise in oncology and cancer biology to lead preclinical research efforts. The successful candidate will direct a team of scientists to expand understanding of cancer mechanisms, support the development of innovative therapies, and advance Astellas’ oncology pipeline.
Key Responsibilities
Scientific Leadership
Lead and guide a diverse team of scientists within the Cancer Biology group.
Drive scientific direction for preclinical oncology research programs.
Oversee the design and development of tumor models and assays for therapeutic evaluation.
Research & Development
Apply expert knowledge of tumor biology—including intrinsic and extrinsic mechanisms of cancer progression and resistance.
Establish in vitro and ex vivo immuno-oncology assays/models for therapeutic assessment.
Support investigation of mechanisms of action and resistance in cancer therapies.
Contribute to program strategy through expertise in oncogenic signaling pathways.
Collaboration & Communication
Manage multiple concurrent projects and act as a cross-functional liaison across research teams.
Communicate scientific findings and strategic recommendations effectively to internal and senior leadership audiences.
Mentor junior researchers, ensuring scientific rigor and excellence across projects.
Required Qualifications
PhD with postdoctoral training in cancer biology, cancer immunotherapy, or a related field.
7+ years postdoctoral experience in academic or industry research.
Proven expertise in solid tumor biology and tumor model development.
Demonstrated success in leading innovative research and mentoring scientific teams.
Strong communication (verbal, written, interpersonal) and leadership skills.
High degree of initiative, problem-solving, and project management capability.
Preferred Qualifications
Understanding of novel oncology modalities, including:
Targeted protein degradation
Antibody-drug conjugates (ADCs)
Bispecific T-cell engagers (BiTEs)
Knowledge of tumor metabolism research methodologies.
Experience with multicellular in vitro models.
Working Environment
On-site role based at the Astellas West Coast Innovation Center, South San Francisco.
Compensation
💰 Salary Range: $140,000 – $200,000
(Final compensation may vary based on experience and qualifications.)
Benefits
Medical, Dental, and Vision Insurance
Generous Paid Time Off (Vacation, Sick, Holidays, Heritage Days, Summer & Winter Breaks)
401(k) with company match and annual contribution
Company-paid Life Insurance
Annual Corporate Bonus & Long-Term Incentive Plan (for eligible roles)
Employee Referral Bonus Program
Equal Opportunity Statement
Astellas is committed to equal opportunity in all aspects of employment, including for individuals with disabilities and protected veterans.
✅ #LI-TR1
🧬 Join Astellas – Turning Innovative Science into Life-Changing Solutions.
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