Lead, Preclinical Development
Job ID: REQ-10048585
Date: April 14, 2025
Location: USA, Cambridge, Massachusetts (Onsite)
Summary:
Technical Research & Development (TRD) at Novartis is seeking a highly motivated individual to join the Chemical and Pharmaceutical Profiling (CPP) team within the discovery pharmaceutics function. The selected candidate will contribute to the development of discovery compounds by providing developability assessments of new chemical entities within a collaborative and cross-functional research environment.
Internal Job Title: Expert, Science and Technology (Level 3/GJFA 6)
About the Role:
As a Lead, Preclinical Development, you will support projects through preclinical stages by acting as a core team member within research teams, providing developability assessments, and recommending physical form and clinical formulation principles based on biopharmaceutical properties. This position demands strong competencies in physical pharmacy, preclinical formulation development, and biopharmaceutics.
Key Responsibilities:
Represent TRD as a member of research stage core project teams, contributing to overall project strategy and success.
Screen phase-appropriate formulations for in vivo assessments and prepare preclinical formulations; author protocols for internal and external formulation labs.
Conduct risk assessments of new compounds and proactively communicate strategies for mitigation.
Perform basic drug substance characterization using XRPD, DSC, TGA, DVS, PLM, and UPLC techniques.
Assess physicochemical properties of small molecules such as solubility, dissolution, particle size, and chemical stability.
Maintain alignment and communication between CPP, research, pharmaceutical development, and third-party collaborators.
Provide timely oral and written communications of project updates to management.
What You Will Bring to the Role:
Advanced degree in pharmaceutical sciences, chemical engineering, or a related scientific field with 3+ years of relevant experience.
Hands-on experience with analytical methods for assessing small molecule compound properties.
Practical experience in developability and biopharmaceutical assessment of low molecular weight compounds.
Ability to manage multiple activities in a fast-paced, dynamic environment.
Strong team collaboration skills and independent working capability.
Excellent written and verbal communication skills, including technical report writing and review.
Desirable Requirements:
Proficiency in solid-state property assessment and its application to formulation development.
Experience applying diverse formulation approaches to enhance bioavailability of poorly soluble or permeable small molecule drug candidates.
Knowledge of biopharmaceutics principles for candidate developability and formulation.
Why Novartis:
Our purpose is to reimagine medicine to improve and extend people’s lives. Our vision is to become the most valued and trusted medicines company in the world, driven by our associates’ passion and commitment. Learn more about us here: Novartis People and Culture
Compensation and Benefits:
Pay Range: $98,700 to $183,300/year (effective 1/1/25 through 12/31/25; subject to market adjustments).
Final compensation determined by geographic location, experience, knowledge, skills, and abilities.
Total compensation may include sign-on bonus, restricted stock units, and discretionary awards.
Full range of benefits including 401(k), medical, financial, and paid time off (vacation, sick, parental leave).
For details: Novartis Life Handbook
Employment Type: Regular, Full-time
Shift Work: No
Accessibility and Reasonable Accommodations:
Novartis is committed to providing reasonable accommodations for individuals with disabilities during the application or hiring process. For assistance, please contact us at:
Phone: +1 (877) 395-2339
Please include the Job Requisition ID (REQ-10048585) in your message.
EEO Statement:
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate based on race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.
Division: Development
Business Unit: Innovative Medicines
Company / Legal Entity: Novartis Pharmaceuticals Corporation (U014/FCRS = US014)
Functional Area: Research & Development
Location: Cambridge, Massachusetts, USA
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